Transcatheter Mitral Valve Replacement With a Novel Dual Stent Bioprosthesis
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There has been great interest in transcatheter mitral valve replacement (TMVR) as a potential therapy for high-risk patients with severe mitral regurgitation, with several distinct device systems undergoing first-in-man clinical studies. The Intrepid TMVR (Medtronic Inc, Redwood City, CA), designed for transapical delivery, comprises 2 interconnected self-expanding nitinol stents: (1) an inner stent that houses a bovine pericardial tissue trileaflet valve and; (2) an outer ring that fixes to the mitral annulus by radial force in a cork-like effect (Figure 1).1 The outer fixation ring is designed to conform to the dynamic anatomy of the mitral valve throughout the cardiac cycle, avoiding distortion of the inner stent and valve.