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Original Article

Incidence, Predictors, and Implications of Reinfarction After Primary Percutaneous Coronary Intervention in ST-Segment–Elevation Myocardial Infarction

The Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trial

Samantha G. Stone, Gregory W. Serrao, Roxana Mehran, Matthew I. Tomey, Bernhard Witzenbichler, Giulio Guagliumi, Jan Z. Peruga, Bruce R. Brodie, Dariusz Dudek, Martin Möckel, Sorin J. Brener, George Dangas, Gregg W. Stone
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https://doi.org/10.1161/CIRCINTERVENTIONS.114.001360
Circulation: Cardiovascular Interventions. 2014;7:543-551
Originally published June 17, 2014
Samantha G. Stone
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Gregory W. Serrao
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Roxana Mehran
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Matthew I. Tomey
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Bernhard Witzenbichler
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Giulio Guagliumi
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Jan Z. Peruga
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Bruce R. Brodie
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Dariusz Dudek
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Martin Möckel
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Sorin J. Brener
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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George Dangas
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Gregg W. Stone
From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology, Medical University, Lodz, Poland (J.Z.P.); Department of Cardiology, LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, NC (B.R.B.); Department of Cardiology, Jagiellonian University, Krakow, Poland (D.D.); Department of Cardiology, Charite/CVK, Berlin, Germany (M.M.); and Department of Cardiology, New York Methodist Hospital, Brooklyn, NY (S.J.B.).
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Abstract

Background—Reinfarction after primary percutaneous coronary intervention in patients with ST-segment–elevation myocardial infarction has negative consequences. Little is known about reinfarction after drug-eluting stents and bivalirudin anticoagulation. We, therefore, sought to determine the incidence, predictors, and implications of reinfarction after primary percutaneous coronary intervention in the contemporary era.

Methods and Results—Outcomes were assessed in 3202 patients undergoing stent implantation for ST-segment–elevation myocardial infarction in the Harmonizing Outcomes with RevascularIZatiON and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial. Independent predictors of reinfarction and mortality were identified by Cox proportional hazards modeling. The cumulative incidence of reinfarction was 1.8% at 30 days, 4.0% at 1 year, and 6.9% at 3 years. Definite stent thrombosis was responsible for 76.3% of reinfarctions occurring within 30 days and 52.0% of all reinfarctions within 3 years. Independent predictors of reinfarction were current smoking, Killip class ≥2, baseline thrombocytosis, multivessel disease, symptom onset-to-balloon time, and total stent length. Randomization to bivalirudin versus heparin plus a glycoprotein IIb/IIIa inhibitor and use of drug-eluting versus bare metal stents were not significant predictors of reinfarction. Reinfarction was a powerful independent predictor of subsequent cardiac mortality (hazard ratio [95% confidence interval]=7.65 [4.47–13.09]; P<0.0001) and all-cause mortality (hazard ratio [95% confidence interval]=2.88 [1.74–4.78]; P<0.0001).

Conclusions—Despite advances in pharmacotherapy and stents, reinfarction after primary percutaneous coronary intervention is not infrequent, in the contemporary era is most often attributable to stent thrombosis, and is strongly associated with subsequent cardiac and all-cause mortality. Further enhancements in drugs and devices to prevent reinfarction are needed to improve outcomes in high-risk patients with ST-segment–elevation myocardial infarction.

Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00433966.

  • myocardial infarction
  • prognosis
  • stents
  • Received January 22, 2014.
  • Accepted May 29, 2014.
  • © 2014 American Heart Association, Inc.
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    Incidence, Predictors, and Implications of Reinfarction After Primary Percutaneous Coronary Intervention in ST-Segment–Elevation Myocardial Infarction
    Samantha G. Stone, Gregory W. Serrao, Roxana Mehran, Matthew I. Tomey, Bernhard Witzenbichler, Giulio Guagliumi, Jan Z. Peruga, Bruce R. Brodie, Dariusz Dudek, Martin Möckel, Sorin J. Brener, George Dangas and Gregg W. Stone
    Circulation: Cardiovascular Interventions. 2014;7:543-551, originally published June 17, 2014
    https://doi.org/10.1161/CIRCINTERVENTIONS.114.001360

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    Incidence, Predictors, and Implications of Reinfarction After Primary Percutaneous Coronary Intervention in ST-Segment–Elevation Myocardial Infarction
    Samantha G. Stone, Gregory W. Serrao, Roxana Mehran, Matthew I. Tomey, Bernhard Witzenbichler, Giulio Guagliumi, Jan Z. Peruga, Bruce R. Brodie, Dariusz Dudek, Martin Möckel, Sorin J. Brener, George Dangas and Gregg W. Stone
    Circulation: Cardiovascular Interventions. 2014;7:543-551, originally published June 17, 2014
    https://doi.org/10.1161/CIRCINTERVENTIONS.114.001360
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